ea0029p150 | Bone & Osteoporosis | ICEECE2012
Caprio M.
, Calanchini M.
, Mammi C.
, Antelmi A.
, Cinti F.
, Fabbri A.
Background: Adipocyte and osteoblast derive from the same mesenchimal progenitor. Age-related decrease in bone mass is accompanied by an increase in marrow adipose tissue. Vitamin D3 (VD) inhibits adipogenesis in 3T3-L1 preadipocytes. Recently it has been demonstrated that alendronate (ALN) inhibits adipogenesis while promoting osteoblast differentiation of mesenchimal stem cells.Aim of the study: To evaluate the in vitro role of ALN on 3T3-L1 adi...